Walther Dirk M, Rapaport Doron
Interfakultäres Institut für Biochemie, Hoppe-Seyler-Str. 4, University of Tübingen, 72076 Tübingen, Germany.
Biochim Biophys Acta. 2009 Jan;1793(1):42-51. doi: 10.1016/j.bbamcr.2008.04.013. Epub 2008 May 3.
Mitochondria are surrounded by two distinct membranes: the outer and the inner membrane. The mitochondrial outer membrane mediates numerous interactions between the mitochondrial metabolic and genetic systems and the rest of the eukaryotic cell. Proteins of this membrane are nuclear-encoded and synthesized as precursor proteins in the cytosol. They are targeted to the mitochondria and inserted into their target membrane via various pathways. This review summarizes our current knowledge of the sorting signals for this specific targeting and describes the mechanisms by which the mitochondrial import machineries recognize precursor proteins, mediate their membrane integration and facilitate assembly into functional complexes.
外膜和内膜。线粒体外膜介导线粒体代谢和遗传系统与真核细胞其他部分之间的多种相互作用。该膜的蛋白质由核基因编码，并在细胞质中以前体蛋白的形式合成。它们被靶向运输到线粒体，并通过各种途径插入到其目标膜中。本综述总结了我们目前对这种特异性靶向分选信号的认识，并描述了线粒体导入机制识别前体蛋白、介导其膜整合并促进组装成功能复合物的机制。
