Vaske Jamie, Makarios Matthew, Boisvert Danielle, Beaver Kevin M, Wright John Paul
Division of Criminal Justice, University of Cincinnati, Cincinnati, OH 45221-0389, United States.
J Affect Disord. 2009 Jan;112(1-3):120-5. doi: 10.1016/j.jad.2008.03.027. Epub 2008 May 27.
Recent research has shown that a polymorphism in the dopamine D2 receptor gene (DRD2) moderates the association between stressful life events and depression. The present study builds off this literature and examines whether DRD2 moderates the effect of violent victimization on depression. Furthermore, the current analyses investigate whether the effects of DRD2 and violent victimization vary by gender and by race for females.
Respondents from waves II and III of the National Longitudinal Study of Adolescent Health (Add Health) completed questionnaires regarding their depressive symptoms and violent victimization experiences (n = 2380).
Multivariate regression results reveal that violent victimization has a strong independent effect on depressive symptoms for Caucasian females. In contrast, violent victimization is only associated with higher levels of depressive symptoms among African American females when they carry at least one A1 allele of DRD2. Results also show that DRD2 has a significant independent effect on depressive symptoms for males and African American females.
The results suggest that African American females who carry the A1 allele of DRD2 may be more vulnerable to the negative effects of violent victimization than African American females who do not carry at least one copy of the A1 allele.
The current study's findings may not generalize to clinical populations, adults, and individuals residing in other countries. In addition, the effects of DRD2 may reflect other polymorphisms that are in linkage with DRD2.
近期研究表明，多巴胺D2受体基因（DRD2）的多态性可调节应激性生活事件与抑郁症之间的关联。本研究基于这一文献展开，探讨DRD2是否调节暴力受害经历对抑郁症的影响。此外，当前分析还研究了DRD2和暴力受害经历的影响在性别和女性种族方面是否存在差异。
来自青少年健康全国纵向研究（Add Health）第二波和第三波的受访者完成了关于其抑郁症状和暴力受害经历的问卷调查（n = 2380）。
多元回归结果显示，暴力受害经历对白人女性的抑郁症状有强烈的独立影响。相比之下，只有当非裔美国女性携带至少一个DRD2的A1等位基因时，暴力受害经历才与较高水平的抑郁症状相关。结果还表明，DRD2对男性和非裔美国女性的抑郁症状有显著的独立影响。
结果表明，携带DRD2的A1等位基因的非裔美国女性可能比不携带至少一份A1等位基因的非裔美国女性更容易受到暴力受害经历的负面影响。
当前研究的结果可能不适用于临床人群、成年人以及居住在其他国家的个体。此外，DRD2的影响可能反映了与DRD2连锁的其他多态性。
