Pycha Armin, Comploj Evi, Martini Thomas, Trenti Emanuela, Mian Christine, Lusuardi Lukas, Lodde Michele, Mian Michael, Palermo Salvatore
Department of Urology, General Hospital of Bolzano, L. Boehler Street 5, Bolzano, Italy.
Eur Urol. 2008 Oct;54(4):825-32. doi: 10.1016/j.eururo.2008.04.068. Epub 2008 May 7.
Few data are available in comparing different incontinent urinary diversions (ICUD).
To compare early, short-term, and long-term complications in three different forms of ICUD.
DESIGN, SETTING, AND PARTICIPANTS: 130 high-risk patients undergoing radical cystectomy and ICUD were prospectively enrolled at one institution. The patients were divided into three groups: ileal conduit (IC), colon conduit (CC), and ureteroureterocutaneostomy (UUCS).
All patients underwent radical cystectomy and one form of ICUD.
The complications observed were prospectively listed and subsequently compared. Statistical analysis was performed using the Pearson's chi-square test. A p-value < or = 0.05 was considered statistically significant.
130 patients with a median age of 71.0 yr (range 46-81) underwent radical cystoprostatectomy (RCP): n=95 (73%) or anterior pelvic exenteration (APE) n=35 (27%) with lymphadenectomy. An IC was performed in 55, a CC in 34, and a UUCS in 41 patients, respectively. A high comorbidity, mainly diabetes, arteriosclerosis, pulmonary insufficiency, and borderline renal function (creatinine>1.5mg%) was found in 12.7% of group 1, in 35.2% of group 2, and in 48.9% of group 3. Overall median follow-up was 16 mo (range 5-84). Perioperative mortality occurred in 1.5%. The overall perioperative diversion-unrelated complication rate was 23.6%. IC showed the lowest rate with 18.1%, followed by CC with 26.4%, and UUCS with 32%, respectively. In contrast, major diversion-related complications occurred in 18.1% of IC, in 5.8% of CC, and none in UUCS. The same was true for late surgical reintervention, with 20% for IC, 5.8% for CC, and 2.4% for UUCS.
Complications are closely related to the method selected. The IC had the highest rate of severe complications as well as surgical reinterventions and late complications in the intestinal tract.
关于比较不同的尿流改道术(ICUD)的资料很少。
比较三种不同形式的ICUD的早期、短期和长期并发症。
设计、地点和参与者:前瞻性纳入一家机构的130例接受根治性膀胱切除术和ICUD的高危患者。患者分为三组:回肠膀胱术(IC)、结肠膀胱术(CC)和输尿管皮肤造口术(UUCS)。
所有患者均接受根治性膀胱切除术和一种形式的ICUD。
前瞻性列出观察到的并发症,随后进行比较。采用Pearson卡方检验进行统计分析。p值≤0.05被认为具有统计学意义。
130例患者,中位年龄71.0岁(范围46 - 81岁),接受了根治性前列腺膀胱切除术(RCP):95例(73%)或盆腔廓清术(APE)35例(27%)并进行了淋巴结清扫。分别有55例、34例和41例患者接受了IC、CC和UUCS手术。在第1组的12.7%、第2组的35.2%和第3组的48.9%患者中发现高合并症,主要为糖尿病、动脉硬化、肺功能不全和临界肾功能(肌酐>1.5mg%)。总体中位随访时间为16个月(范围5 - 84个月)。围手术期死亡率为1.5%。总体围手术期与尿流改道无关的并发症发生率为23.6%。IC发生率最低,为18.1%,其次是CC,为26.4%,UUCS为32%。相比之下,与尿流改道相关的主要并发症在IC组中发生率为18.1%,CC组为5.8%,UUCS组无发生。晚期手术再次干预情况也是如此,IC组为20%,CC组为5.8%,UUCS组为2.4%。
并发症与所选方法密切相关。IC组严重并发症以及手术再次干预和肠道晚期并发症的发生率最高。