Olive Jennifer L, Ballard Kevin D, Miller James J, Milliner Beth A
Department of Health and Sport Sciences, University of Louisville, Louisville, KY, USA.
Metabolism. 2008 Jun;57(6):831-7. doi: 10.1016/j.metabol.2008.01.028.
Metabolic and vascular abnormalities have been found in individuals with type 2 diabetes mellitus (T2D). Family history is often associated with increased risk of the development of T2D. We sought to determine if young, sedentary, insulin-sensitive individuals with a family history of T2D (FH+) have a reduced resting energy expenditure (REE) and vascular endothelial function compared with individuals who have no family history of T2D (FH-). The REE was determined in 18 FH+ individuals and 15 FH- individuals using indirect open-circuit calorimetry. Vascular endothelial function was measured via flow-mediated dilation (FMD) of the brachial artery. C-reactive protein and interleukin-6 were also measured to look at vascular inflammation. Body composition was measured via bioelectrical impedance analysis to determine fat-free mass and fat mass for each individual. Insulin resistance was calculated using the homeostasis model assessment equation and fasting insulin and glucose concentrations. Subjects (n = 42) were approximately 26 years old and had normal fasting serum insulin or glucose concentrations. The REE normalized for body weight (kilocalories per day per kilogram body weight) was significantly reduced in the FH+ women compared with FH- women (P < .001) but not in the men. The FMD was significantly reduced (34.3%) in the FH+ group compared with the FH- in women (P = .002). However, no between-group difference in FMD was present in male subjects (P = .376). Young, healthy, insulin-sensitive women with a family history of T2D have reduced whole-body metabolic rate and vascular endothelial function compared with those with no family history of disease. These differences in whole-body metabolic rate and vascular endothelial function were not present in male subjects.
在2型糖尿病（T2D）患者中已发现代谢和血管异常。家族史通常与T2D发病风险增加有关。我们试图确定，与无T2D家族史（FH-）的个体相比，有T2D家族史（FH+）的年轻、久坐、胰岛素敏感个体的静息能量消耗（REE）和血管内皮功能是否降低。使用间接开路量热法测定了18名FH+个体和15名FH-个体的REE。通过肱动脉的血流介导的扩张（FMD）测量血管内皮功能。还测量了C反应蛋白和白细胞介素-6以观察血管炎症。通过生物电阻抗分析测量身体成分，以确定每个个体的去脂体重和脂肪量。使用稳态模型评估方程以及空腹胰岛素和葡萄糖浓度计算胰岛素抵抗。受试者（n = 42）年龄约为26岁，空腹血清胰岛素或葡萄糖浓度正常。与FH-女性相比，FH+女性的体重标准化REE（每千克体重每天千卡数）显著降低（P <.001），但男性中未出现这种情况。与FH-女性相比，FH+组女性的FMD显著降低（34.3%）（P =.002）。然而，男性受试者中FMD在组间无差异（P =.376）。与无疾病家族史的女性相比，有T2D家族史的年轻、健康、胰岛素敏感女性的全身代谢率和血管内皮功能降低。全身代谢率和血管内皮功能的这些差异在男性受试者中不存在。
