Neff Ryan L, Farrar William B, Kloos Richard T, Burman Kenneth D
Department of Surgery, Division of Surgical Oncology, The Ohio State University, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, Columbus, OH 43210-1228, USA.
Endocrinol Metab Clin North Am. 2008 Jun;37(2):525-38, xi. doi: 10.1016/j.ecl.2008.02.003.
Anaplastic thyroid cancer is an uncommon, typically lethal malignancy of older adults with no effective systemic therapy. The mean survival time is usually less than 6 months from the time of diagnosis and, unfortunately, this outcome is not fundamentally altered by available treatments. Histologic tissue confirmation is recommended if the diagnosis is not absolutely certain to exclude tumors with better prognosis or that require different treatment. Patency of the airway should be kept in mind throughout the patient's course and individuals with impending airway obstruction, in the absence of imminent death from other sites of disease, should be considered for a tracheostomy to secure the airway. Enrollment in meaningful clinical trials should be given the highest priority at all decision points.
间变性甲状腺癌是一种罕见的、通常致命的老年恶性肿瘤，目前尚无有效的全身治疗方法。从诊断时起，平均生存时间通常不到6个月，不幸的是，现有治疗方法并未从根本上改变这一结局。如果诊断不能绝对确定，建议进行组织学组织确认，以排除预后较好或需要不同治疗的肿瘤。在患者整个病程中都应牢记气道通畅问题，对于即将出现气道梗阻的患者，若不存在其他部位疾病导致的临近死亡情况，应考虑行气管切开术以确保气道安全。在所有决策点，应将参加有意义的临床试验放在最高优先级。
