Vidal Christine N, Nicolson Rob, Boire Jean-Yves, Barra Vincent, DeVito Timothy J, Hayashi Kiralee M, Geaga Jennifer A, Drost Dick J, Williamson Peter C, Rajakumar Nagalingam, Toga Arthur W, Thompson Paul M
Laboratory of Neuro Imaging, Brain Mapping Division, Department Neurology, UCLA School of Medicine, Los Angeles, California, USA.
Psychiatry Res. 2008 Jul 15;163(2):106-15. doi: 10.1016/j.pscychresns.2007.11.002. Epub 2008 May 27.
In this study, a computational mapping technique was used to examine the three-dimensional profile of the lateral ventricles in autism. T1-weighted three-dimensional magnetic resonance images of the brain were acquired from 20 males with autism (age: 10.1+/-3.5 years) and 22 male control subjects (age: 10.7+/-2.5 years). The lateral ventricles were delineated manually and ventricular volumes were compared between the two groups. Ventricular traces were also converted into statistical three-dimensional maps, based on anatomical surface meshes. These maps were used to visualize regional morphological differences in the thickness of the lateral ventricles between patients and controls. Although ventricular volumes measured using traditional methods did not differ significantly between groups, statistical surface maps revealed subtle, highly localized reductions in ventricular size in patients with autism in the left frontal and occipital horns. These localized reductions in the lateral ventricles may result from exaggerated brain growth early in life.
在本研究中，使用一种计算映射技术来检查自闭症患者侧脑室的三维轮廓。从20名患有自闭症的男性（年龄：10.1±3.5岁）和22名男性对照受试者（年龄：10.7±2.5岁）获取大脑的T1加权三维磁共振图像。手动勾勒出侧脑室，并比较两组之间的脑室体积。基于解剖表面网格，脑室轨迹也被转换为统计三维图谱。这些图谱用于可视化患者和对照者之间侧脑室壁厚度的区域形态差异。尽管使用传统方法测量的脑室体积在两组之间没有显著差异，但统计表面图谱显示，自闭症患者左额角和枕角的脑室大小有细微的、高度局部化的减小。侧脑室的这些局部减小可能是由于生命早期大脑过度生长所致。
