Vekasi J, Koltai K, Gaal V, Toth A, Juricskay I, Kesmarky G
Department of Ophthalmology, University of Pecs, Medical School, Pecs, Hungary.
Clin Hemorheol Microcirc. 2008;39(1-4):385-9.
Hemorheological factors play an important role in the pathogenesis of severe complications of diabetes. The diabetic retinopathy is the leading cause of blindness in patients aged 20-65 years. In our study we investigated the effect of aspirin on the hemorheological parameters in patients with different diabetic retinopathies. Hemorheological parameters (hematocrit, fibrinogen, plasma and whole blood viscosity, red blood cell aggregation) of diabetic patients with non-proliferative (n=14, mean age: 66 years) and proliferative retinopathy (n=8, mean age: 48 years) were measured. The results between the two groups were compared: twelve patients were taking aspirin (group A), while ten patients were not (group B).Hematocrit, fibrinogen, plasma and whole blood viscosity were significantly higher (p < 0.05-0.001) in patients with diabetic retinopathy who did not take aspirin than in those who took. No significant difference was observed in red blood cell aggregation parameters between the two groups. We could not find any significant difference in the measured parameters between patients with non-proliferative and proliferative diabetic retinopathy. According to our results, all the measured hemorheological parameters were in the pathological range, although aspirin treatment could decrease these factors and thus may help to prevent the progression of severe diabetic retinopathy and perhaps blindness.
血液流变学因素在糖尿病严重并发症的发病机制中起重要作用。糖尿病视网膜病变是20 - 65岁患者失明的主要原因。在我们的研究中，我们调查了阿司匹林对不同糖尿病视网膜病变患者血液流变学参数的影响。测量了非增殖性糖尿病视网膜病变患者（n = 14，平均年龄：66岁）和增殖性视网膜病变患者（n = 8，平均年龄：48岁）的血液流变学参数（血细胞比容、纤维蛋白原、血浆和全血粘度、红细胞聚集性）。比较了两组结果：12例患者服用阿司匹林（A组），10例患者未服用（B组）。未服用阿司匹林的糖尿病视网膜病变患者的血细胞比容、纤维蛋白原、血浆和全血粘度显著高于服用阿司匹林的患者（p < 0.05 - 0.001）。两组之间红细胞聚集参数未观察到显著差异。我们未发现非增殖性和增殖性糖尿病视网膜病变患者在测量参数上有任何显著差异。根据我们的结果，所有测量的血液流变学参数均处于病理范围内，尽管阿司匹林治疗可降低这些因素，从而可能有助于预防严重糖尿病视网膜病变的进展甚至失明。
