Vekasi J, Marton Z S, Kesmarky G, Cser A, Russai R, Horvath B
Department of Ophthalmology, University of Pecs Medical School, Hungary.
Clin Hemorheol Microcirc. 2001;24(1):59-64.
Hemorheological factors play an important role in the pathogenesis of different cardiovascular diseases. Diabetes mellitus resulting in micro- and macroangiopathies is one of the major risk factors for cardiovascular diseases. In our present study the hemorheological parameters (hematocrit, plasma fibrinogen level, plasma and whole blood viscosity, red blood cell aggregation) of 30 diabetic patients (mean age: 57 +/- 12 years) and 30 healthy volunteers (mean age: 31 +/- 10 years) were examined. The fundus appearance of patients showed diabetic retinopathy; non-proliferative stage in 22 cases, preproliferative or proliferative stage in 8 cases. The measured hemorheological parameters of the examined patients were in the pathological range and were significantly higher than those of healthy volunteers (hematocrit: p < 0.01; plasma fibrinogen: p < 0.001; plasma viscosity: p < 0.01; whole blood viscosity: p < 0.001; red blood cell aggregation: p < 0.01). In our study there was not significant difference in the hemorheologic variables of patients with different stages of retinopathy. Our results propose the importance of hemorheologic factors in the development of diabetic microangiopathy.
血液流变学因素在不同心血管疾病的发病机制中起重要作用。导致微血管和大血管病变的糖尿病是心血管疾病的主要危险因素之一。在我们目前的研究中，检测了30例糖尿病患者（平均年龄：57±12岁）和30名健康志愿者（平均年龄：31±10岁）的血液流变学参数（血细胞比容、血浆纤维蛋白原水平、血浆和全血粘度、红细胞聚集）。患者的眼底表现显示为糖尿病视网膜病变；22例为非增殖期，8例为增殖前期或增殖期。所检测患者的血液流变学参数处于病理范围，且显著高于健康志愿者（血细胞比容：p<0.01；血浆纤维蛋白原：p<0.001；血浆粘度：p<0.01；全血粘度：p<0.001；红细胞聚集：p<0.01）。在我们的研究中，不同视网膜病变阶段患者的血液流变学变量没有显著差异。我们的结果提示血液流变学因素在糖尿病微血管病变发展中的重要性。
