Kanoh Kaneo, Okada Ario, Adachi Kyoko, Imagawa Hiroshi, Nishizawa Mugio, Matsuda Satoru, Shizuri Yoshikazu, Utsumi Ryutaro
Marine Biotechnology Institute Co., Ltd, Kamaishi, Iwate, Japan.
J Antibiot (Tokyo). 2008 Mar;61(3):142-8. doi: 10.1038/ja.2008.123.
Ascochytatin, a new spirodioxynaphthalene metabolite produced by a marine-derived fungus, was found from a screening program focused on the bacterial two-component regulatory system. The structure of ascochytatin was determined by spectroscopic methods, including NMR and MS. The relative stereochemistry was determined by an X-ray crystallographic analysis, and the absolute stereochemistry was determined by the modified Mosher's method.
曲霉他汀是一种由海洋来源真菌产生的新型螺二氧萘代谢产物，它是在一项针对细菌双组分调节系统的筛选项目中发现的。曲霉他汀的结构通过包括核磁共振（NMR）和质谱（MS）在内的光谱方法确定。相对立体化学通过X射线晶体学分析确定，绝对立体化学通过改良的莫舍尔方法确定。
