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曲霉他汀,一种由海洋来源的真菌曲霉属NGB4产生的新型生物活性螺二氧萘代谢产物。

Ascochytatin, a novel bioactive spirodioxynaphthalene metabolite produced by the marine-derived fungus, Ascochyta sp. NGB4.

作者信息

Kanoh Kaneo, Okada Ario, Adachi Kyoko, Imagawa Hiroshi, Nishizawa Mugio, Matsuda Satoru, Shizuri Yoshikazu, Utsumi Ryutaro

机构信息

Marine Biotechnology Institute Co., Ltd, Kamaishi, Iwate, Japan.

出版信息

J Antibiot (Tokyo). 2008 Mar;61(3):142-8. doi: 10.1038/ja.2008.123.

Abstract

Ascochytatin, a new spirodioxynaphthalene metabolite produced by a marine-derived fungus, was found from a screening program focused on the bacterial two-component regulatory system. The structure of ascochytatin was determined by spectroscopic methods, including NMR and MS. The relative stereochemistry was determined by an X-ray crystallographic analysis, and the absolute stereochemistry was determined by the modified Mosher's method.

摘要

曲霉他汀是一种由海洋来源真菌产生的新型螺二氧萘代谢产物,它是在一项针对细菌双组分调节系统的筛选项目中发现的。曲霉他汀的结构通过包括核磁共振(NMR)和质谱(MS)在内的光谱方法确定。相对立体化学通过X射线晶体学分析确定,绝对立体化学通过改良的莫舍尔方法确定。

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