Henkel KGaA Henkelstrasse 67, POB 1100, 40191 Düsseldorf, Germany.
Int J Cosmet Sci. 1999 Oct;21(5):299-311. doi: 10.1046/j.1467-2494.1999.211929.x.
During aging, the epidermis and dermis become thin and an efficient anti-aging product should be able to stimulate the metabolism of senescent fibroblast and keratinocytes, in order to increase the quantity of extra-cellular matrix components such as collagen and glycosaminoglycans. A study performed in parallel on an in vitro skin equivalent model, and in vivo, with human volunteers, demonstrated the efficacy of one specific soya biopeptide for anti-aging properties. Such a biopeptide induces a significant increase of glycosaminoglycans synthesis in vitro and in vivo after a one-month treatment. We also showed that this new cosmetic ingredient is able to stimulate favourably the collagen synthesis in vitro and in vivo. This study provided the proof for anti-aging properties of a new soya biopeptide and also validated the skin equivalent model developed for this experimentation as an alternative method to animal or human testing for some cosmetic efficacy evaluations.
随着年龄的增长，表皮和真皮层会变薄，有效的抗衰老产品应该能够刺激衰老成纤维细胞和角质细胞的新陈代谢，以增加细胞外基质成分（如胶原蛋白和糖胺聚糖）的数量。在体外皮肤等效模型和体内人体志愿者中进行的平行研究证明了一种特定的大豆生物肽具有抗衰老特性。这种生物肽在一个月的治疗后，能够显著增加体外和体内糖胺聚糖的合成。我们还表明，这种新型化妆品成分能够在体外和体内促进胶原蛋白的合成。这项研究为一种新的大豆生物肽的抗衰老特性提供了证据，也验证了为该实验开发的皮肤等效模型作为替代动物或人体测试的方法，用于某些化妆品功效评估。
