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编码rstC基因的丝状弧菌噬菌体fs2与CTX噬菌体整合到同一染色体区域[已修正]。

Filamentous vibriophage fs2 encoding the rstC gene integrates into the same chromosomal region as the CTX phage [corrected].

作者信息

Nguyen Dong Tu, Nguyen Binh Minh, Tran Huy Hoang, Ngo Tuan Cuong, Le Thanh Huong, Nguyen Hoai Thu, Albert M John, Iwami Mamoru, Ehara Masahiko

机构信息

Department of Bacteriology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.

出版信息

FEMS Microbiol Lett. 2008 Jul;284(2):225-30. doi: 10.1111/j.1574-6968.2008.01200.x. Epub 2008 May 23.

DOI:10.1111/j.1574-6968.2008.01200.x
PMID:18503544
Abstract

The genome of the filamentous phage of Vibrio cholerae fs2 was found to contain rstC and rstB1 (truncated) genes downstream of ORF500. att-fs2-dir and att-fs2-rev sequences homologous to that of att-CTXphi were found between orf500 and rstC of the fs2 genome. This prompted us to search for the integration site of fs2 in the genomes of V. cholerae O1 and O139. The genome of fs2 was found to integrate downstream of attRS of the CTXphi phage, which integrated into chromosome I of V. cholerae O1 and O139. When infected with fs2, a fimbriate strain of V. cholerae O1 appeared to reduce fimbrial production in an adult rabbit ileal loop assay.

摘要

霍乱弧菌丝状噬菌体fs2的基因组被发现含有位于ORF500下游的rstC和rstB1（截短的）基因。在fs2基因组的orf500和rstC之间发现了与att-CTXphi同源的att-fs2-dir和att-fs2-rev序列。这促使我们在霍乱弧菌O1和O139的基因组中寻找fs2的整合位点。发现fs2的基因组整合在CTXphi噬菌体的attRS下游，而CTXphi噬菌体整合到霍乱弧菌O1和O139的染色体I中。当用fs2感染时，霍乱弧菌O1的一个菌毛菌株在成年兔回肠袢试验中似乎减少了菌毛的产生。

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