中国沙发/座椅皮炎流行的原因可能是对富马酸二甲酯的接触性过敏，富马酸二甲酯是一种新型强效接触致敏剂。
The cause of the Chinese sofa/chair dermatitis epidemic is likely to be contact allergy to dimethylfumarate, a novel potent contact sensitizer.
作者信息
Rantanen T
机构信息
Dermatology and Allergology, Central Hospital, Päijät-Häme Social and Health Care Group, FI-15850 Lahti, Finland.
出版信息
Br J Dermatol. 2008 Jul;159(1):218-21. doi: 10.1111/j.1365-2133.2008.08622.x. Epub 2008 Jul 1.
BACKGROUND
A small epidemic of severe contact dermatitis cases related to newly acquired sofas and chairs has surpassed the news threshold in Finland and the U.K.
OBJECTIVES
To study affected patients and to identify the cause.
METHODS
Five patients with contact dermatitis related to a newly purchased chair or sofa were studied. Furniture samples were analysed by gas chromatography-mass spectrometry. Compounds were identified using a mass spectrum library and measured semiquantitatively. Patch tests were performed with commercial standard allergens, furniture upholstery and chemicals found in the analysis.
RESULTS
Patch tests with commercial allergens did not solve the problem. Up to 470 microg kg(-1) of dimethylfumarate was found in chairs. The patients showed strong positive patch test reactions to upholstery fabric samples and to dimethylfumarate, down to a level of 1 p.p.m. in the most severe case.
CONCLUSIONS
The cause of the Chinese sofa/chair dermatitis epidemic is likely to be contact allergy to dimethylfumarate, a novel potent contact sensitizer.
背景
在芬兰和英国，与新购置的沙发和椅子相关的严重接触性皮炎小规模流行已成为新闻热点。
目的
研究受影响的患者并确定病因。
方法
对5例与新购买的椅子或沙发相关的接触性皮炎患者进行了研究。采用气相色谱 - 质谱联用仪对家具样本进行分析。利用质谱库鉴定化合物并进行半定量测定。使用市售标准变应原、家具内饰及分析中发现的化学物质进行斑贴试验。
结果
使用市售变应原进行斑贴试验未能解决问题。在椅子中发现高达470微克/千克的富马酸二甲酯。患者对内饰织物样本和富马酸二甲酯表现出强烈的斑贴试验阳性反应，在最严重的病例中，该物质浓度低至百万分之一时仍呈阳性。
结论
中国沙发/椅子性皮炎流行的原因可能是对富马酸二甲酯的接触性过敏，富马酸二甲酯是一种新型强效接触致敏剂。
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