Lidén Carola, Skare Lizbet, Nise Gun, Vahter Marie
Occupational and Environmental Dermatology, Department of Medicine in Solna, Karolinska Institutet, Stockholm, Sweden.
Contact Dermatitis. 2008 Jun;58(6):347-54. doi: 10.1111/j.1600-0536.2008.01326.x.
Nickel, chromium, and cobalt are important skin sensitizers. Better knowledge about skin exposure is needed for more efficient prevention. We have previously developed acid wipe sampling for assessment of skin exposure to metals.
To apply the acid wipe sampling technique in some occupations where intense contact with metallic items occurs and to gather experience for the design of future workplace studies.
18 volunteers (carpenters, locksmiths, cashiers, and secretaries as controls) participated. They performed their normal tasks during a job session for exposure. Samples were taken from fingers and palms by acid wipe sampling, and analysis of metals was performed by inductively coupled plasma mass spectrometer.
The metals were detected in all samples, and the amount of nickel was larger than that of chromium and cobalt. Fingers were more exposed than palms. 8-h exposure to nickel was calculated and was highest in locksmiths (mean 3.784 mug/cm(2), range 1.846-5.028 mug/cm(2)) followed by carpenters, cashiers, and secretaries.
The acid wipe sampling technique is suitable for studies of skin exposure to nickel, chromium, and cobalt in the workplace. The sampling efficiency of acid wipe sampling is high. The amounts of nickel deposited on skin in carpenters, locksmiths, and cashiers are judged capable of eliciting allergic contact dermatitis.
镍、铬和钴是重要的皮肤致敏剂。为了更有效地预防，需要对皮肤接触情况有更深入的了解。我们之前已开发出酸擦拭采样法来评估皮肤对金属的接触情况。
将酸擦拭采样技术应用于一些与金属物品有密切接触的职业中，并为未来工作场所研究的设计积累经验。
18名志愿者（木匠、锁匠、收银员和秘书作为对照）参与。他们在一个工作时段内进行正常工作以接触金属。通过酸擦拭采样从手指和手掌采集样本，并用电感耦合等离子体质谱仪对金属进行分析。
在所有样本中均检测到金属，镍的含量高于铬和钴。手指比手掌接触更多。计算了8小时的镍接触量，锁匠中最高（平均3.784微克/平方厘米，范围1.846 - 5.028微克/平方厘米），其次是木匠、收银员和秘书。
酸擦拭采样技术适用于工作场所皮肤对镍、铬和钴接触情况的研究。酸擦拭采样的采样效率高。木匠、锁匠和收银员皮肤上沉积的镍量被判定有可能引发过敏性接触性皮炎。
