Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, DK-2900 Hellerup, Denmark.
Contact Dermatitis. 2011 Jan;64(1):32-6. doi: 10.1111/j.1600-0536.2010.01819.x.
EU legislation has reduced the epidemic of nickel contact allergy affecting the consumer, and shifted the focus towards occupational exposure. The acid wipe sampling technique was developed to quantitatively determine skin exposure to metals.
To assess the clinical usefulness of the acid wipe sampling technique as part of the diagnostic investigation for occupational nickel allergy-associated hand dermatitis.
Six patients with vesicular dermatitis on the hands were included. Acid wipe sampling of skin and patch testing with a nickel sulfate dilution series were performed.
Nickel was detected in all samples from the hands. In all patients, the nickel content on the hands was higher than on the non-exposed control area.
Occupational exposure to nickel-releasing items raised the nickel content on exposed skin as compared with a non-exposed control site. Nickel-reducing measures led to complete symptom relief in all cases. In cases of a positive nickel patch test reaction and hand eczema, patients should perform the dimethylglyoxime (DMG) test on metallic items at home and at work. The acid wipe sampling technique is useful for the diagnosis of occupational hand eczema following screening with the inexpensive DMG test.
欧盟立法减少了影响消费者的镍接触过敏流行，并将重点转向职业暴露。酸擦拭采样技术被开发出来以定量测定金属的皮肤暴露。
评估酸擦拭采样技术作为职业性镍过敏相关手部接触性皮炎诊断研究的一部分的临床实用性。
纳入 6 例手部水疱性皮炎患者。进行皮肤酸擦拭采样和镍硫酸盐稀释系列斑贴试验。
所有手部样本均检测到镍。在所有患者中，手部的镍含量均高于非暴露对照区。
与非暴露对照部位相比，释放镍的物品的职业暴露会增加暴露皮肤的镍含量。采取减少镍措施后，所有病例的症状均完全缓解。对于镍斑贴试验阳性和手部湿疹的患者，应在家中和工作中对金属物品进行二甲基乙二醛 (DMG) 测试。酸擦拭采样技术对于通过廉价的 DMG 测试进行筛选后的职业性手部湿疹的诊断有用。
