Al-Humoud Hani, Alhumoud Ekhlas, Al-Hilali Nabieh
College of Medicine, Kuwait University, Safat, Kuwait.
Ther Apher Dial. 2008 Jun;12(3):202-4. doi: 10.1111/j.1744-9987.2008.00572.x.
Therapeutic plasma exchange (TPE) has been used for the treatment of hyperlipidemic pancreatitis (HLP) with variable results. Eight patients with acute HLP were studied and treated with TPE, in addition to dietary fat restriction and lipid lowering agents. TPE lowered plasma levels of amylase (723.63 +/- 391.70-189.25 +/- 71.26 IU/L, P = 0.002), triglycerides (110.28 +/- 146.39-38.47 +/- 48.79 mmol/L, P = 0.048) and cholesterol (13.37 +/- 7.97-3.84 +/- 1.34 mmol/L, P < 0.001). Clinical symptoms improved in all patients with no resultant complications, and follow up of the patients for 12 months revealed no recurrence of pancreatitis. Thus, TPE is effective in lowering amylase, triglycerides and cholesterol levels, improves the acute attack of hyperlipidemic pancreatitis, and aids in preventing recurrent attacks.
治疗性血浆置换（TPE）已用于治疗高脂血症性胰腺炎（HLP），但效果不一。本研究纳入8例急性HLP患者，除进行饮食脂肪限制和使用降脂药物外，还采用TPE进行治疗。TPE可降低血浆淀粉酶水平（从723.63±391.70降至189.25±71.26 IU/L，P = 0.002）、甘油三酯水平（从110.28±146.39降至38.47±48.79 mmol/L，P = 0.048）以及胆固醇水平（从13.37±7.97降至3.84±1.34 mmol/L，P < 0.001）。所有患者的临床症状均有改善，且无并发症发生，对患者进行12个月的随访发现胰腺炎无复发。因此，TPE在降低淀粉酶、甘油三酯和胆固醇水平方面有效，可改善高脂血症性胰腺炎的急性发作，并有助于预防复发。
