Fenger R V, Linneberg A, Tvede M, Ostergaard C
Research Centre for Prevention and Health, Copenhagen University Hospital Glostrup, the Capital Region of Denmark.
Epidemiol Infect. 2009 Feb;137(2):278-83. doi: 10.1017/S0950268808000800. Epub 2008 May 27.
The incidence of Clostridium difficile-associated infections is increasing, but it remains to be defined whether any change in the seroprevalence of C. difficile has also occurred. In a population-based study of the general adult population, 734 subjects, aged 15-69 years, were examined on two occasions 8 years apart (1990 and 1998) for the presence of antibodies against C. difficile in serum. The overall seroprevalence of C. difficile increased significantly from 19% in 1990 to 27% in 1998 (P<0.0001). The seroprevalence increased with increasing age in both 1990 and 1998, but the increase was about four times higher in 1998 than in 1990. In conclusion, the observed increase in seroprevalence suggests a higher exposure to C. difficile in the general Danish adult population.
艰难梭菌相关感染的发病率正在上升，但艰难梭菌血清阳性率是否也发生了变化仍有待确定。在一项针对一般成年人群的基于人群的研究中，对734名年龄在15至69岁之间的受试者进行了两次检查，两次检查间隔8年（1990年和1998年），以检测血清中抗艰难梭菌抗体的存在情况。艰难梭菌的总体血清阳性率从1990年的19%显著上升至1998年的27%（P<0.0001）。1990年和1998年血清阳性率均随年龄增长而上升，但1998年的上升幅度约为1990年的四倍。总之，观察到的血清阳性率上升表明丹麦一般成年人群中接触艰难梭菌的机会增加。
