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本文引用的文献

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Characterisation and carriage ratio of Clostridium difficile strains isolated from a community-dwelling elderly population in the United Kingdom.从英国社区居住的老年人群体中分离出的艰难梭菌菌株的特征和携带率。
PLoS One. 2011;6(8):e22804. doi: 10.1371/journal.pone.0022804. Epub 2011 Aug 23.
2
The role of toxin A and toxin B in Clostridium difficile infection.艰难梭菌感染中毒素 A 和毒素 B 的作用。
Nature. 2010 Oct 7;467(7316):711-3. doi: 10.1038/nature09397. Epub 2010 Sep 15.
3
Treatment with monoclonal antibodies against Clostridium difficile toxins.针对艰难梭菌毒素的单克隆抗体治疗。
N Engl J Med. 2010 Jan 21;362(3):197-205. doi: 10.1056/NEJMoa0907635.
4
Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI).血清抗毒素 B 抗体与预防复发性艰难梭菌感染（CDI）相关。
Vaccine. 2010 Jan 22;28(4):965-9. doi: 10.1016/j.vaccine.2009.10.144. Epub 2009 Nov 24.
5
Toxin B is essential for virulence of Clostridium difficile.毒素B对于艰难梭菌的毒力至关重要。
Nature. 2009 Apr 30;458(7242):1176-9. doi: 10.1038/nature07822. Epub 2009 Mar 1.
6
Prospective derivation and validation of a clinical prediction rule for recurrent Clostridium difficile infection.复发性艰难梭菌感染临床预测规则的前瞻性推导与验证
Gastroenterology. 2009 Apr;136(4):1206-14. doi: 10.1053/j.gastro.2008.12.038. Epub 2008 Dec 13.
7
Increasing seroprevalence of Clostridium difficile in an adult Danish general population.丹麦成年普通人群中艰难梭菌血清阳性率上升。
Epidemiol Infect. 2009 Feb;137(2):278-83. doi: 10.1017/S0950268808000800. Epub 2008 May 27.
8
A double-blind randomized controlled trial of fusidic acid and metronidazole for treatment of an initial episode of Clostridium difficile-associated diarrhoea.一项关于夫西地酸和甲硝唑治疗艰难梭菌相关性腹泻初发 episode 的双盲随机对照试验。 注：这里“episode”结合语境可理解为“发病情况”等类似意思，具体准确含义需结合更多医学背景知识进一步确定。
J Antimicrob Chemother. 2004 Jul;54(1):211-6. doi: 10.1093/jac/dkh278. Epub 2004 May 26.
9
Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea.针对毒素A的抗体反应与预防艰难梭菌复发性腹泻之间的关联。
Lancet. 2001 Jan 20;357(9251):189-93. doi: 10.1016/S0140-6736(00)03592-3.
10
Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A.艰难梭菌无症状携带与抗毒素A的IgG抗体血清水平
N Engl J Med. 2000 Feb 10;342(6):390-7. doi: 10.1056/NEJM200002103420604.

艰难梭菌感染患者对毒素A和毒素B的IgG抗体反应。

IgG antibody response to toxins A and B in patients with Clostridium difficile infection.

作者信息

Wullt M, Norén T, Ljungh A, Åkerlund T

机构信息

Infectious Diseases Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.

出版信息

Clin Vaccine Immunol. 2012 Sep;19(9):1552-4. doi: 10.1128/CVI.00210-12. Epub 2012 Jul 11.

DOI:10.1128/CVI.00210-12
PMID:22787196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3428380/
Abstract

IgG antibodies against Clostridium difficile toxins A and B were followed in controls and in patients with an initial C. difficile infection (CDI). Of the 50 CDI patients, 38 were cured and 12 developed recurrence. Compared to controls, patients had significantly lower anti-toxin A and B IgGs at inclusion, but the subsequent levels rose slightly regardless of clinical outcome. The results imply that the general serum reactivity against toxins A and B in the population reduces the risk of CDI, which suggests implications for vaccine strategies.

摘要

在对照组以及初次感染艰难梭菌（CDI）的患者中，对针对艰难梭菌毒素A和B的IgG抗体进行了跟踪研究。在50例CDI患者中，38例治愈，12例复发。与对照组相比，患者在纳入研究时抗毒素A和B的IgG水平显著较低，但无论临床结果如何，随后这些水平均略有上升。结果表明，人群中针对毒素A和B的总体血清反应性可降低CDI风险，这对疫苗策略具有启示意义。