Spencer Jeremy P E
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 6AP, UK.
Br J Nutr. 2008 May;99 E Suppl 1:ES60-77. doi: 10.1017/S0007114508965776.
Emerging evidence suggests that dietary phytochemicals, in particular flavonoids, may exert beneficial effects on the central nervous system by protecting neurons against stress-induced injury, by suppressing neuroinflammation and by improving cognitive function. It is likely that flavonoids exert such effects, through selective actions on different components of a number of protein kinase and lipid kinase signalling cascades, such as the phosphatidylinositol-3 kinase (PI3K)/Akt, protein kinase C and mitogen-activated protein kinase (MAPK) pathways. This review explores the potential inhibitory or stimulatory actions of flavonoids within these pathways, and describes how such interactions are likely to underlie neurological effects through their ability to affect the activation state of target molecules and/or by modulating gene expression. Future research directions are outlined in relation to the precise site(s) of action of flavonoids within signalling pathways and the sequence of events that allow them to regulate neuronal function.
新出现的证据表明，膳食植物化学物质，尤其是黄酮类化合物，可能通过保护神经元免受应激诱导的损伤、抑制神经炎症和改善认知功能，对中枢神经系统产生有益影响。黄酮类化合物可能通过对多种蛋白激酶和脂质激酶信号级联反应的不同成分（如磷脂酰肌醇-3激酶（PI3K）/Akt、蛋白激酶C和丝裂原活化蛋白激酶（MAPK）途径）的选择性作用来发挥这些效应。本综述探讨了黄酮类化合物在这些途径中的潜在抑制或刺激作用，并描述了这种相互作用如何可能通过影响靶分子的激活状态和/或调节基因表达而成为神经学效应的基础。还概述了与黄酮类化合物在信号通路中的精确作用位点以及使其调节神经元功能的事件顺序相关的未来研究方向。
