Rębas Elżbieta
Department of Molecular Neurochemistry, Medical University of Lodz, 90-419 Lodz, Poland.
Int J Mol Sci. 2025 May 16;26(10):4763. doi: 10.3390/ijms26104763.
Neurodegenerative and mood disorders represent growing medical and social problems, many of which are produced by oxidative stress, neuroinflammation, disruption in the metabolism of various neurotransmitters, and some disturbances in lipid/carbohydrate homeostasis. Biologically active plant compounds, including flavonoids, have been shown to exert a positive impact on central nervous system function. This review assesses the studies of naturally occurring flavonoids belonging to various polyphenol subclasses and their mechanisms of neuroprotective action, especially against neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. Most of the studied phytochemicals possess anti-oxidative, anti-inflammatory, and neuroprotective properties. These phytochemicals have been considered as compounds that reduce the risk of developing Alzheimer's and Parkinson's diseases and can be used in the treatment of neurological diseases. The neuroprotective actions of some flavonoids may entail mechanisms that regulate reactive oxygen species generation and modify inflammatory pathways, and they should be considered as therapeutic agents.
神经退行性疾病和情绪障碍已成为日益严重的医学和社会问题，其中许多是由氧化应激、神经炎症、各种神经递质代谢紊乱以及脂质/碳水化合物稳态的某些失调引起的。包括黄酮类化合物在内的具有生物活性的植物化合物已被证明对中枢神经系统功能有积极影响。本综述评估了属于各种多酚亚类的天然存在的黄酮类化合物的研究及其神经保护作用机制，特别是针对阿尔茨海默病和帕金森病等神经退行性疾病。大多数研究的植物化学物质具有抗氧化、抗炎和神经保护特性。这些植物化学物质被认为是降低患阿尔茨海默病和帕金森病风险的化合物，可用于治疗神经疾病。一些黄酮类化合物的神经保护作用可能涉及调节活性氧生成和改变炎症途径的机制，它们应被视为治疗剂。
