细胞ATP对脂肪酸生物合成的神秘作用。细胞ATP适度降低时产生刺激作用，而增加时则产生抑制作用。

Enigmatic effect of cellular ATP on fatty acid biosynthesis. Stimulation by moderate decrease and inhibition by increase of cellular ATP.

作者信息

Geelen Math J H, Harris Robert A, Van den Bergh Simon G

机构信息

Laboratory of Veterinary Biochemistry, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

出版信息

FEBS Lett. 2008 Jun 25;582(15):2242-6. doi: 10.1016/j.febslet.2008.05.020. Epub 2008 May 27.

DOI:10.1016/j.febslet.2008.05.020

PMID:18503772

Abstract

The cellular ATP concentration was tested for its effect on fatty acid biosynthesis from glucose in hepatocytes. ATP was manipulated by adding increasing concentrations of cycloheximide, amytal, atractyloside, 2,4-dinitrophenol or adenosine. A slight decrease in cellular ATP coincided with a stimulation of fatty acid biosynthesis whereas a further lowering of cellular ATP resulted in a gradual inhibition. Increasing the cellular ATP level by titration with adenosine had the opposite effect. These results are in line with the suggestion that fatty acid biosynthesis from glucose is an energy-yielding process which is stimulated by a moderate drop in cellular ATP.

摘要

检测了细胞ATP浓度对肝细胞中由葡萄糖合成脂肪酸的影响。通过添加浓度不断增加的环己酰亚胺、阿米妥、苍术苷、2,4-二硝基苯酚或腺苷来调控ATP。细胞ATP稍有下降时，脂肪酸生物合成受到刺激，而细胞ATP进一步降低则导致逐渐抑制。用腺苷滴定增加细胞ATP水平则产生相反的效果。这些结果与以下观点一致，即由葡萄糖合成脂肪酸是一个产能过程，会受到细胞ATP适度下降的刺激。