Reimann-Berg Nicola, Murua Escobar Hugo, Nolte Ingo, Bullerdiek Jörn
Center for Human Genetics, University of Bremen, Leobener Str. ZHG, 28359 Bremen, Germany.
Cancer Genet Cytogenet. 2008 Jun;183(2):114-6. doi: 10.1016/j.cancergencyto.2008.02.009.
Klinefelter syndrome has been described in various species in addition to humans, including cat, pig, horse, and dog. It is associated with low levels of male hormones, sterility, breast enlargement, and small testes. Patients with Klinefelter syndrome have a higher risk for several malignancies. Knowledge about genetic disorders of the dog is comparatively sparse. This is mainly due to the difficult canine karyotypic pattern. We present the case of a canine patient with clinically and cytogenetically confirmed Klinefelter syndrome who developed a testicular tumor at a very early age. Testicular tumors are common in dogs, normally affecting elderly patients (median age, >9 years). In the present case, however, the dog was only 5 years old, allowing the conclusion that the XXY constitution may have promoted the early onset of testicular tumor disease.
除人类外，克氏综合征在包括猫、猪、马和狗在内的多种物种中都有描述。它与雄性激素水平低、不育、乳房增大和睾丸小有关。克氏综合征患者患几种恶性肿瘤的风险更高。关于狗的遗传疾病的知识相对较少。这主要是由于犬类染色体核型模式复杂。我们报告了一例经临床和细胞遗传学确诊为克氏综合征的犬科患者，该患者在很小的年龄就患上了睾丸肿瘤。睾丸肿瘤在狗中很常见，通常影响老年患者（中位年龄，>9岁）。然而，在本病例中，这只狗只有5岁，由此可以得出结论，XXY染色体构成可能促使了睾丸肿瘤疾病的早发。
