Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Sex Dev. 2012;6(1-3):46-60. doi: 10.1159/000332740. Epub 2011 Oct 14.
The molecular steps in normal sexual development were largely discovered by studying patients and animal models with disorders of sexual development (DSD). Although several types of DSD have been reported in the cat and dog, which are often strikingly similar to human DSD, these have been infrequently utilized to contribute to our knowledge of mammalian sexual development. Canine and feline cases of DSD with sufficient evidence to be considered as potential models are summarized in this report. The consensus DSD terminology, and reference to previous terminology, is used to foster adoption of a common nomenclature that will facilitate communication and collaboration between veterinarians, physicians, and researchers. To efficiently utilize these unique resources as molecular tools continue to improve, it will be helpful to deposit samples from valuable cases into repositories where they are available to contribute to our understanding of sexual development, and thus improve human and animal health.
正常性发育的分子步骤主要是通过研究患有性发育障碍（DSD）的患者和动物模型来发现的。尽管猫和狗中已经报道了几种类型的 DSD，它们通常与人类 DSD 非常相似，但这些很少被用于增加我们对哺乳动物性发育的了解。本报告总结了具有足够证据可被视为潜在模型的犬和猫 DSD 病例。使用共识 DSD 术语，并参考以前的术语，有助于采用通用命名法，促进兽医、医生和研究人员之间的沟通和协作。为了有效地利用这些作为分子工具的独特资源，随着技术的不断改进，将有价值病例的样本存入存储库中，以便为我们对性发育的理解做出贡献，从而改善人类和动物的健康，这将是有帮助的。
