Dyr Wanda, Ligieza Janusz, Kostowski Wojciech
Institute of Psychiatry and Neurology, Department of Pharmacology and Physiology of the Nervous System, Warszawa, Poland.
Alcohol. 2008 Sep;42(6):509-12. doi: 10.1016/j.alcohol.2008.04.001. Epub 2008 May 27.
The present study investigated the effect of the cannabinoid CB(1) receptor antagonist, rimonabant (SR-141716) on ethanol intake in selectively bred alcohol-preferring Warsaw High-Preferring rats. Ethanol (10% vol/vol) and food were available in daily 4-h limited access period while water was available ad libitum. The administration (i.p.) of single 2.5 and 5.0-mg/kg doses of rimonabant preferentially reduced ethanol intake, whereas a 10 mg/kg dose of rimonabant similarly reduced both ethanol and food intake. Our result extends the suppressive effect of cannabinoid CB(1) receptor antagonist to the ethanol drinking behavior in Warsaw High-Preferring line of rats. The result also supports a growing body of literature indicating that the cannabinoid CB(1) receptor is involved in motivational and appetitive properties of ethanol.
本研究调查了大麻素CB(1)受体拮抗剂利莫那班（SR-141716）对选择性培育的高嗜酒华沙大鼠乙醇摄入量的影响。在每日4小时的有限获取期内可获得乙醇（10%体积/体积）和食物，而水可随意获取。单次腹腔注射2.5毫克/千克和5.0毫克/千克剂量的利莫那班可优先降低乙醇摄入量，而10毫克/千克剂量的利莫那班同样降低了乙醇和食物摄入量。我们的结果将大麻素CB(1)受体拮抗剂的抑制作用扩展至华沙高嗜酒品系大鼠的乙醇饮用行为。该结果还支持了越来越多的文献表明大麻素CB(1)受体参与乙醇的动机和食欲特性。
