大麻素受体拮抗剂SR 141716可阻止嗜酒大鼠习得饮酒行为。
The cannabinoid receptor antagonist SR 141716 prevents acquisition of drinking behavior in alcohol-preferring rats.
作者信息
Serra S, Carai M A, Brunetti G, Gomez R, Melis S, Vacca G, Colombo G, Gessa G L
机构信息
Neuroscienze S.c.a r.l., via Palabanda 9, I-09123, Cagliari, Italy.
出版信息
Eur J Pharmacol. 2001 Nov 2;430(2-3):369-71. doi: 10.1016/s0014-2999(01)01379-6.
The cannabinoid CB(1) receptor antagonist, N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3-pyrazole-carboxamide) (SR 141716); 0.3-3 mg/kg, i.p., twice daily for 10 days), prevented the acquisition of alcohol drinking behavior in rats genetically selected for alcohol preference (Sardinian alcohol-preferring (sP) rats), having the free choice between alcohol (10%, v/v) and water. The results suggest that activation of cannabinoid CB(1) receptors is essential for the acquisition of alcohol drinking behavior in animals with a genetically determined alcohol preference.
大麻素CB(1)受体拮抗剂N-哌啶基-5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-3-吡唑甲酰胺(SR 141716)，腹腔注射，剂量为0.3 - 3毫克/千克，每日两次，共10天，可阻止经基因筛选对酒精有偏好的大鼠（撒丁岛酒精偏好(sP)大鼠）习得酒精饮用行为，这些大鼠可在酒精(10%, v/v)和水之间自由选择。结果表明，大麻素CB(1)受体的激活对于具有基因决定的酒精偏好的动物习得酒精饮用行为至关重要。
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