Colombo G, Agabio R, Fà M, Guano L, Lobina C, Loche A, Reali R, Gessa G L
C.N.R. Center for Neuropharmacology, University of Cagliari, Italy.
Alcohol Alcohol. 1998 Mar-Apr;33(2):126-30. doi: 10.1093/oxfordjournals.alcalc.a008368.
The present study assessed the efficacy of the cannabinoid CB1 receptor antagonist, SR-141716, in reducing voluntary ethanol intake in selectively bred Sardinian alcohol-preferring (sP) rats. Ethanol (10%, v/v) and food were available in daily 4 h scheduled access periods; water was present 24 h/day. The acute administration of a 2.5 and a 5 mg/kg dose of SR-141716 selectively reduced ethanol intake, whereas a 10 mg/kg dose of SR-141716 reduced to a similar extent both ethanol and food intake. These results suggest that the cannabinoid CB1 receptor is involved in the mediation of the ethanol-reinforcing effects in sP rats.
本研究评估了大麻素CB1受体拮抗剂SR - 141716在减少选择性培育的撒丁岛嗜酒（sP）大鼠自愿乙醇摄入量方面的疗效。在每天4小时的定时获取时间段内可获得乙醇（10%，v/v）和食物；水全天24小时供应。急性给予2.5毫克/千克和5毫克/千克剂量的SR - 141716可选择性降低乙醇摄入量，而10毫克/千克剂量的SR - 141716则在相似程度上降低乙醇和食物摄入量。这些结果表明，大麻素CB1受体参与介导sP大鼠的乙醇强化作用。
