Hansen T, Klimek L, Bittinger F, Hansen I, Capitani F, Weber A, Gatti A, Kirkpatrick C J
Institut für Pathologie, Johannes-Gutenberg-Universität Mainz, Langenbeckstrasse 1, 55101, Mainz.
Pathologe. 2008 Jul;29(4):311-3. doi: 10.1007/s00292-008-1006-2.
Persistent subcutaneous nodules arise at the injection sites of aluminium hydroxide-absorbed hyposensitization solutions. We present a hitherto unreported phenomenon in aluminium granuloma. Two years after specific immunotherapy, a patient suffered increasingly from urticaria. Besides inflammatory infiltrates surrounding necrotic areas, microscopy of the specimen revealed numerous mast cells surrounding the necrotic tissue areas. The histological phenomenon of increased mast cell populations in aluminium granuloma might reflect the association with urticaria, which is probably more frequent than previously reported.
持续存在的皮下结节出现在氢氧化铝吸附的减敏溶液注射部位。我们呈现了铝肉芽肿中一种迄今未报道的现象。特异性免疫治疗两年后，一名患者荨麻疹病情日益加重。除了坏死区域周围的炎性浸润外，标本显微镜检查显示坏死组织区域周围有大量肥大细胞。铝肉芽肿中肥大细胞数量增加的组织学现象可能反映了与荨麻疹的关联，这种关联可能比之前报道的更为常见。
