Pinkernelle J G, Stelter L, Hamm B, Teichgräber U
Institut für Radiologie, Charité Universitätsmedizin Berlin, Berlin.
Rofo. 2008 Jun;180(6):505-13. doi: 10.1055/s-2008-1027290.
The demand for highly resolved small animal MRI for the purpose of biomedical research has increased constantly. Dedicated small animal MRI scanners working at ultra high field strengths from 4.7 to 7.0 T and even above are MRI at its best. However, using high resolution RF coils in clinical scanners up to 3.0 T, small animal MRI can achieve highly resolved images showing excellent tissue contrast. In fact, in abundant experimental studies, clinical MRI is used for small animal imaging. Mostly clinical RF coils in the single-loop design are applied. In addition, custom-built RF coils and even gradient inserts are used in a clinical scanner. For the reduction of moving artifacts, special MRI-compatible animal ECG und respiration devices are available. In conclusion, clinical devices offer broad availability, are less expense in combination with good imaging performance and provide a translational nature of imaging results.
出于生物医学研究目的，对高分辨率小动物磁共振成像（MRI）的需求一直在不断增加。工作在4.7至7.0 T甚至更高的超高场强下的专用小动物MRI扫描仪堪称MRI的最佳设备。然而，在高达3.0 T的临床扫描仪中使用高分辨率射频线圈，小动物MRI也能够获得显示出优异组织对比度的高分辨率图像。事实上，在大量的实验研究中，临床MRI被用于小动物成像。大多采用单环设计的临床射频线圈。此外，定制的射频线圈甚至梯度插入件也被用于临床扫描仪中。为了减少运动伪影，有专门的与MRI兼容的动物心电图和呼吸装置可供使用。总之，临床设备具有广泛的可用性，与良好的成像性能相结合成本较低，并且提供成像结果的可转化性。
