Lauenstein Thomas C, Sharma Puneet, Hughes Timothy, Heberlein Keith, Tudorascu Dana, Martin Diego R
Department of Radiology, Emory University Hospital, Atlanta, Georgia, USA.
J Magn Reson Imaging. 2008 Jun;27(6):1448-54. doi: 10.1002/jmri.21350.
To test the theoretical benefits of a spectral attenuated inversion-recovery (SPAIR) fat-suppression (FS) technique in clinical abdominal MRI by comparison to conventional inversion-recovery (IR) FS combined with T2-weighted (T2W) partial Fourier single shot fast spin echo (SSFSE).
1.5T MRI studies of the abdomen were performed in 28 patients with liver lesions (hemangiomas n = 14; metastases n = 14). T2W sequences were acquired using IR and SPAIR SSFSE. Measurements included retroperitoneal and mesenteric fat signal-to-noise (SNR) to evaluate FS; liver lesion contrast-to-noise (CNR) to evaluate bulk water signal recovery effects; and bowel wall delineation to evaluate susceptibility and physiological motion effects.
SPAIR-SSFSE images produce significantly improved FS and liver lesion CNR. The mean SNR of the retroperitoneal and mesenteric fat for SPAIR SSFSE was 20.5 +/- 10.2 (+/-1 SD) and 12.7 +/- 6.2, compared to 43.2 +/- 24.1 (P = 0.000006) and 29.3 +/- 16.8 (P = 0.0000005) for IR-SSFSE. SPAIR-SSFSE images produced higher CNR for both hemangiomas CNR = 164 +/- 88 vs. 126 +/- 83 (P = 0.00005) and metastases CNR = 75 +/- 27 vs. 53 +/- 19 (P = 0.007). Bowel wall visualization was significantly improved using SPAIR-SSFSE (P = 0.002).
The theoretical benefits of SPAIR over conventional IR FS translate into significant multiple improvements that can be measured on clinical abdominal MRI scans.
通过与传统反转恢复（IR）脂肪抑制（FS）联合T2加权（T2W）部分傅里叶单次激发快速自旋回波（SSFSE）技术进行比较，测试频谱衰减反转恢复（SPAIR）脂肪抑制技术在临床腹部MRI中的理论优势。
对28例肝脏病变患者（14例血管瘤；14例转移瘤）进行1.5T腹部MRI检查。使用IR和SPAIR SSFSE序列采集T2W图像。测量指标包括腹膜后和肠系膜脂肪的信噪比（SNR）以评估脂肪抑制效果；肝脏病变的对比噪声比（CNR）以评估总体水信号恢复效果；以及肠壁显示情况以评估敏感性和生理运动效果。
SPAIR-SSFSE图像在脂肪抑制和肝脏病变CNR方面有显著改善。SPAIR SSFSE的腹膜后和肠系膜脂肪平均SNR分别为20.5±10.2（±1标准差）和12.7±6.2，而IR-SSFSE分别为43.2±24.1（P = 0.000006）和29.3±16.8（P = 0.0000005）。SPAIR-SSFSE图像在血管瘤（CNR = 164±88 vs. 126±83，P = 0.00005）和转移瘤（CNR = 75±27 vs. 53±19，P = 0.007）方面均产生了更高的CNR。使用SPAIR-SSFSE时肠壁可视化显著改善（P = 0.002）。
与传统IR脂肪抑制相比，SPAIR的理论优势转化为在临床腹部MRI扫描中可测量的显著多项改善。
