单序列T1加权快速场回波磁共振成像与多序列磁共振成像在定量动脉粥样硬化斑块中富含脂质坏死核心方面的比较。

Comparison of single-sequence T1w TFE MRI with multisequence MRI for the quantification of lipid-rich necrotic core in atherosclerotic plaque.

作者信息

Cappendijk Vincent C, Heeneman Sylvia, Kessels Alfons G H, Cleutjens Kitty B J M, Schurink Geert Willem H, Welten Rob J Th J, Mess Werner H, van Suylen Robert-Jan, Leiner Tim, Daemen Mat J A P, van Engelshoven Jos M A, Kooi M Eline

机构信息

Department of Radiology, Maastricht University Hospital, Maastricht, The Netherlands.

出版信息

J Magn Reson Imaging. 2008 Jun;27(6):1347-55. doi: 10.1002/jmri.21360.

DOI:10.1002/jmri.21360

PMID:18504754

Abstract

PURPOSE

To prospectively determine the accuracy of semiquantitative analysis of the amount of lipid-rich necrotic core (LRNC) in atherosclerotic plaque using multi- as well as single-sequence T1-weighted (w) turbo field echo (TFE) MRI. Histology served as a reference standard.

MATERIALS AND METHODS

Sixty-four symptomatic patients with carotid stenosis > or =70% were included and underwent endarterectomy after an MRI scan. Two MRI readers classified relative signal intensities in regions of interest in the vessel wall. The amount of LRNC was determined semiquantitatively using an algorithm based on fixed combinations of multiple MR pulse sequences as well as solely based on T1w TFE images. Interreader agreement was expressed by intraclass correlation coefficients (ICCs). Agreement between MRI and histology was determined by linear regression (R).

RESULTS

Interreader reproducibility for quantification of LRNC was high (ICC, 95% confidence interval [CI]): multisequence 0.86 (0.77-0.94), and single sequence 0.91 (0.85-0.95). There was good agreement between MRI and histology for both MR readers for quantification based on multisequence as well as single sequence MRI, 0.80 < or = R < or = 0.85 (P < 0.0001).

CONCLUSION

The amount of LRNC using single-sequence T1w TFE MRI is a reproducible, accurate, and fast way to quantify LRNC in carotid atherosclerotic plaque.

摘要

目的

前瞻性地确定使用多序列以及单序列T1加权（w）快速场回波（TFE）磁共振成像（MRI）对动脉粥样硬化斑块中富含脂质坏死核心（LRNC）的量进行半定量分析的准确性。组织学作为参考标准。

材料与方法

纳入64例症状性颈动脉狭窄≥70%的患者，在MRI扫描后接受了颈动脉内膜切除术。两名MRI阅片者对血管壁感兴趣区域的相对信号强度进行分类。使用基于多个MR脉冲序列固定组合的算法以及仅基于T1w TFE图像对LRNC的量进行半定量测定。阅片者间的一致性用组内相关系数（ICC）表示。MRI与组织学之间的一致性通过线性回归（R）确定。

结果

LRNC定量的阅片者间可重复性较高（ICC，95%置信区间[CI]）：多序列为0.86（0.77 - 0.94），单序列为0.91（0.85 - 0.95）。对于基于多序列以及单序列MRI进行定量分析的两种MR阅片者，MRI与组织学之间均具有良好的一致性，0.80≤R≤0.85（P < 0.0001）。