Pryczynicz Anna, Guzińska-Ustymowicz Katarzyna, Kemona Andrzej, Czyzewska Jolanta
Departments of General Pathomorphology, Medical University of Białystok, Białystok, Poland.
Anticancer Res. 2008 Mar-Apr;28(2B):1399-404.
The epidermal growth factor family members: EGF, EGFR and the c-erbB-2(HER-2/neu) gene product have been found to play a role in carcinomas of the stomach, liver, breast, ovary and lungs. Recent reports have indicated that they are also involved in the growth of pancreatic ductal carcinoma, its invasiveness and metastasis.
Thirty-six patients with pancreatic ductal carcinoma were analysed with respect to sex, age, histological type, malignancy grade (G), pTN status (pTN), local lymph node involvement and distant metastasis. The tumor levels of EGF, EGFR and c-erbB-2 expression were determined immunohistochemically.
Expression of c-erbB-2 was observed in 24/36 cases, EGF in 13/36 cases and EGFR in 18/36 cases. Overexpression of EGF and EGFR was associated with metastasis to lymph nodes and other organs. A correlation was also found between EGF expression and the presence of EGFR in the tumour. The expression of c-erbB-2 protein was not found to correlate with any parameters.
EGF and EGFR play a key role in neoplastic spread through lymph node involvement and metastasis to other organs.
已发现表皮生长因子家族成员：表皮生长因子（EGF）、表皮生长因子受体（EGFR）和c-erbB-2（HER-2/neu）基因产物在胃癌、肝癌、乳腺癌、卵巢癌和肺癌中发挥作用。最近的报告表明，它们也参与胰腺导管癌的生长、侵袭和转移。
对36例胰腺导管癌患者进行了性别、年龄、组织学类型、恶性程度（G）、pTN分期（pTN）、局部淋巴结受累情况及远处转移的分析。采用免疫组织化学方法测定肿瘤组织中EGF、EGFR和c-erbB-2的表达水平。
36例患者中，24例c-erbB-2呈阳性表达，13例EGF呈阳性表达，18例EGFR呈阳性表达。EGF和EGFR的过表达与淋巴结及其他器官转移相关。肿瘤组织中EGF表达与EGFR表达之间也存在相关性。未发现c-erbB-2蛋白表达与任何参数相关。
EGF和EGFR在肿瘤通过淋巴结受累及转移至其他器官的过程中起关键作用。
