Tobita Kosuke, Kijima Hiroshi, Dowaki Shoichi, Kashiwagi Hiroyuki, Ohtani Yasuo, Oida Yasuhisa, Yamazaki Hitoshi, Nakamura Masato, Ueyama Yoshito, Tanaka Makiko, Inokuchi Sadaki, Makuuchi Hiroyasu
Department of Surgery, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan.
Int J Mol Med. 2003 Mar;11(3):305-9.
Pancreatic cancer is a malignant tumor with an extremely poor prognosis. The mechanisms of the aggressive growth and metastasis are not yet extensively understood. Over-expression of epidermal growth factor receptor (EGFR) was suggested to be associated with malignant transformation of pancreatic cancer. We examined EGFR expression in 77 cases of invasive ductal adenocarcinoma of the pancreas, and analyzed the relation between the EGFR expression pattern and clinicopathological factors. EGFR immunoreactivity was detected in 41.6% (32/77) of human pancreatic cancers; i.e. diffuse expression in 32.5% (25/77) and focal expression in 9.1% (7/77). The EGFR expression was associated with gender (p<0.05), histological differentiation (p<0.05) and metastatic status of TNM classification (p<0.01). The observations suggested that EGFR expression plays important roles in metastasis, especially liver metastasis and recurrence of human pancreatic cancer.
胰腺癌是一种预后极差的恶性肿瘤。其侵袭性生长和转移机制尚未得到广泛了解。表皮生长因子受体（EGFR）的过度表达被认为与胰腺癌的恶性转化有关。我们检测了77例胰腺浸润性导管腺癌中EGFR的表达情况，并分析了EGFR表达模式与临床病理因素之间的关系。在41.6%（32/77）的人类胰腺癌中检测到EGFR免疫反应性；即32.5%（25/77）为弥漫性表达，9.1%（7/77）为局灶性表达。EGFR表达与性别（p<0.05）、组织学分化（p<0.05）及TNM分期的转移状态（p<0.01）相关。这些观察结果表明，EGFR表达在人类胰腺癌的转移尤其是肝转移和复发中起重要作用。
