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外用5%咪喹莫特乳膏治疗阴茎鲍温病。

Bowen's disease of the penis treated with topical imiquimod 5% cream.

作者信息

Taliaferro Sumayah J, Cohen George F

机构信息

Veterans Affairs Medical Center, Washington, DC, USA.

出版信息

J Drugs Dermatol. 2008 May;7(5):483-5.

Abstract

Bowen's disease of the penis is relatively uncommon, but the prevalence has increased in recent years. Risk factors for penile squamous cell cancer include smoking, infection with human papilloma virus (HPV), immunosuppression, and a history of conditions such as balanitis, phimosis, and lichen sclerosis et atrophicus. Bowen's disease of the penis is often managed by local excision of the lesion. Less invasive methods are now employed more frequently and include laser ablation, electrodessication and curettage, cryosurgery, application of5-fluorouracil, and topical imiquimod 5% cream. This case report describes the successful treatment of Bowen's disease of the penis with topical imiquimod 5% cream in a 42-year-old African American male with human immunodeficiency virus (HIV) disease.

摘要

阴茎鲍恩病相对少见,但近年来其发病率有所上升。阴茎鳞状细胞癌的危险因素包括吸烟、人乳头瘤病毒(HPV)感染、免疫抑制以及诸如龟头炎、包茎和萎缩性硬化苔藓等疾病史。阴茎鲍恩病通常通过局部切除病变来治疗。现在,侵入性较小的方法使用得更为频繁,包括激光消融、电干燥刮除术、冷冻手术、5-氟尿嘧啶应用以及外用5%咪喹莫特乳膏。本病例报告描述了一名42岁患有人类免疫缺陷病毒(HIV)疾病的非裔美国男性,使用外用5%咪喹莫特乳膏成功治疗阴茎鲍恩病的情况。

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