Su Xianbin, Surry David S, Spandl Richard J, Spring David R
Department of Chemistry, University of Cambridge, Cambridge, UK.
Org Lett. 2008 Jun 19;10(12):2593-6. doi: 10.1021/ol8009545.
Using an atropdiastereoselective oxidative biaryl coupling as the key step, the total synthesis of the ellagitannin natural product sanguiin H-5 is reported. Both organomagnesium and organozinc based metalation methodologies were used to efficiently construct the strained medium-ring core of the natural product.
报道了以一种对映体选择性氧化联芳基偶联反应作为关键步骤，对鞣花单宁天然产物山桑子素H-5进行全合成的过程。有机镁和有机锌基金属化方法均被用于高效构建该天然产物的张力中环核心结构。
