Proschan Michael A, Nason Martha
Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive, MSC 7609, Bethesda, Maryland 20892-7609, USA.
Biometrics. 2009 Mar;65(1):316-22. doi: 10.1111/j.1541-0420.2008.01053.x. Epub 2008 May 23.
Two-by-two tables arise in a number of diverse settings in biomedical research, including analysis of data from a clinical trial with a binary outcome and gating methods in flow cytometry to separate antigen-specific immune responses from general immune responses. These applications offer interesting challenges concerning what we should really be conditioning on-the total number of events, the number of events in the control condition, etc. We give several biostatistics examples to illustrate the complexities of analyzing what appear to be simple data.
在生物医学研究的许多不同场景中都会出现二乘二列联表，包括对具有二元结果的临床试验数据进行分析，以及在流式细胞术中使用门控方法将抗原特异性免疫反应与一般免疫反应区分开来。这些应用在我们真正应该基于什么进行条件设定方面提出了有趣的挑战——事件总数、对照条件下的事件数等等。我们给出几个生物统计学的例子来说明分析看似简单的数据的复杂性。
