Lancaster Group-Coty, International Research Center, MONACO, France.
Int J Cosmet Sci. 1998 Oct;20(5):283-95. doi: 10.1046/j.1467-2494.1998.181621.x.
The aim of this study was to compare the characteristics of an O/W emulsion and a W/O/W emulsion, formulated with similar ingredients. The physical properties of these two types of vehicles were characterized first. Using three types of in vitro models, human skin biopsies, nitrate acetate cellulose membranes and human reconstituted epidermis, the delivery potential of each vehicle for one hydrophilic drug, caffeine, was compared. The assessment of physical parameters, such as particle size, conductivity and rheological behavior enabled the nature of the test emulsions to be clearly identified. Clear differences were observed in the ability of each type of emulsion to deliver caffeine. Whatever the nature of the membrane used for the pharmacokinetic study, the absorption of caffeine was roughly two-fold lower (2.6 for human skin) when the W/O/W multiple emulsion was used as the vehicle. The concomitant determination of physical and kinetic properties of these two test emulsions allowed the W/O/W multiple emulsion and a simple O/W emulsion to be clearly differentiated.
本研究旨在比较 O/W 型乳剂和 W/O/W 型乳剂的特性，两种乳剂均采用类似的成分制备。首先对这两种类型载体的物理性质进行了表征。使用三种体外模型（人体皮肤活检、硝酸纤维素酯膜和人重建表皮），比较了每种载体对一种亲水性药物咖啡因的传递潜力。评估物理参数，如粒径、电导率和流变行为，可明确识别测试乳剂的性质。观察到每种类型的乳剂递送咖啡因的能力存在明显差异。无论用于药代动力学研究的膜的性质如何，当 W/O/W 型多重乳剂作为载体时，咖啡因的吸收大约低两倍（人体皮肤为 2.6）。这两种测试乳剂的物理和动力学性质的同时测定，使得 W/O/W 型多重乳剂和简单的 O/W 型乳剂能够明确区分。
