Larsen J, Hetland G, Skaug K, Maeland A
Blodbank og immunologisk avdeling, Ullevål sykehus, Oslo.
Tidsskr Nor Laegeforen. 1991 Mar 10;111(7):825-8.
Our findings show that hepatitis B-virus was transmitted by blood from two hepatitis B-surface-antigen (HBsAg)-negative but hepatitis B-coreantibody (anti-HBc)-positive donors. Blood donors and recipients were also tested for antibodies against the recently identified hepatitis C-virus (HCV). We found that two anti-HCV-positive donors with no known history of clinical hepatitis were chronic, infective carriers of HCV. The prevalence of anti-HCV in our blood donor population was 0.47% and ALT and anti-HBc testing was of no help for tracing the anti-HCV positives. We recommend that, in addition to HBsAg screening at each donation, donors are tested for anti-HBc and anti-HCV once. Individuals with a history of parenteral virus hepatitis should not be accepted as blood donors.
我们的研究结果表明,乙肝病毒是通过两名乙肝表面抗原(HBsAg)阴性但乙肝核心抗体(抗-HBc)阳性的献血者的血液传播的。还对献血者和受血者进行了针对最近发现的丙型肝炎病毒(HCV)的抗体检测。我们发现,两名无临床肝炎病史的抗-HCV阳性献血者是HCV的慢性感染携带者。我们献血人群中抗-HCV的患病率为0.47%,谷丙转氨酶(ALT)和抗-HBc检测对追踪抗-HCV阳性者并无帮助。我们建议,除了每次献血时进行HBsAg筛查外,还应对献血者进行一次抗-HBc和抗-HCV检测。有肠道外病毒性肝炎病史的个人不应被接受为献血者。