Lee A W, Pfaff D W
Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA.
J Physiol Sci. 2008 Aug;58(4):213-20. doi: 10.2170/physiolsci.RV007008. Epub 2008 May 29.
The first demonstration of how biochemical changes in neurons in specific parts of the brain direct a complete mammalian behavior derived from the effects of estrogens in hypothalamic neurons that facilitate lordosis behavior, the primary reproductive behavior of female quadrupeds (Pfaff. Estrogens and Brain Function. 1980; Pfaff. Drive: Neurobiological and Molecular Mechanisms of Sexual Motivation. 1999). Sex behaviors depend on sexual arousal that in turn depends on a primitive function: generalized CNS arousal (Pfaff. Brain Arousal and Information Theory. 2006). Here we summarize one of the ways in which a generalized arousal transmitter, norepinephrine, can influence the electrical excitability of ventromedial hypothalamic cells in a way that will foster female sex behavior.
关于大脑特定部位神经元的生化变化如何指导完整的哺乳动物行为的首次证明，源于雌激素对下丘脑神经元的作用，这种作用促进了脊柱前凸行为，即雌性四足动物的主要生殖行为（普法夫。《雌激素与脑功能》。1980年；普法夫。《驱动力：性动机的神经生物学和分子机制》。1999年）。性行为取决于性唤起，而性唤起又取决于一种原始功能：中枢神经系统的普遍唤起（普法夫。《脑唤起与信息理论》。2006年）。在这里，我们总结了一种方式，即一种普遍的唤起递质去甲肾上腺素，可以以促进雌性性行为的方式影响腹内侧下丘脑细胞的电兴奋性。
