Badger Stephen A, O'Donnell Mark E, Sharif Muhammed A, McMaster Cyril, Young Ian S, Soong Chee V
Department of Vascular and Endovascular Surgery, Belfast City Hospital, Lisburn Road, Belfast, Northern Ireland, United Kingdom.
Angiology. 2009 Feb-Mar;60(1):115-9. doi: 10.1177/0003319708318380. Epub 2008 May 27.
Abdominal aortic aneurysm is common. The aim of this study was to assess the effect of smoking on prevalence and management. Patients attending the vascular unit and appropriate controls were prospectively recruited. A smoking history revealed tobacco exposure in pack years. Serum cotinine was assessed biochemically. Independent risk factors were statistically determined. In all, 202 (186 men) patients were recruited, with 202 (197 men) controls. A total of 69 patients tested positive for cotinine, whereas 39 controls were positive (P = .001). Smoking and ischemic heart disease were significant predictors for aneurysm prevalence. Cardiac disease emerged as a more important predictor than smoking in symptomatic patients. In noncardiac patients, smoking and hypercholesterolemia were significant risk factors. Smoking is a significant predictor for aneurysm development. In high-risk patients, the cardiac disease process is the most important factor, with control of this imperative. However, in noncardiac patients, smoking cessation and lipid-lowering therapy are crucial.
腹主动脉瘤很常见。本研究的目的是评估吸烟对其患病率及治疗的影响。前瞻性招募了血管科就诊的患者及合适的对照。通过吸烟史得出以包年计算的烟草暴露量。通过生化方法评估血清可替宁。统计确定独立危险因素。总共招募了202名患者（186名男性）和202名对照（197名男性）。共有69名患者可替宁检测呈阳性，而39名对照呈阳性（P = 0.001）。吸烟和缺血性心脏病是动脉瘤患病率的重要预测因素。在有症状的患者中，心脏病比吸烟成为更重要的预测因素。在无心脏病的患者中，吸烟和高胆固醇血症是显著危险因素。吸烟是动脉瘤发生的重要预测因素。在高危患者中，心脏病进程是最重要的因素，必须加以控制。然而，在无心脏病的患者中，戒烟和降脂治疗至关重要。
