Farhat Mirna H, Shamseddine Ali I, Tawil Ayman N, Berjawi Ghina, Sidani Charif, Shamseddeen Wael, Barada Kassem A
Division of Hematology- Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, 110 72020, Lebanon.
World J Gastroenterol. 2008 May 28;14(20):3224-30. doi: 10.3748/wjg.14.3224.
To study the factors that may affect survival of cholangiocarcinoma in Lebanon.
A retrospective review of the medical records of 55 patients diagnosed with cholangio-carcinoma at the American University of Beirut between 1990 and 2005 was conducted. Univariate and multivariate analyses were performed to determine the impact of surgery, chemotherapy, body mass index, bilirubin level and other factors on survival.
The median survival of all patients was 8.57 mo (0.03-105.2). Univariate analysis showed that low bilirubin level (< 10 mg/dL), radical surgery and chemotherapy administration were significantly associated with better survival (P = 0.012, 0.038 and 0.038, respectively). In subgroup analysis on patients who had no surgery, chemotherapy administration prolonged median survival significantly (17.0 mo vs 3.5 mo, P = 0.001). Multivariate analysis identified only low bilirubin level < 10 mg/dL and chemotherapy administration as independent predictors associated with better survival (P < 0.05).
Our data show that palliative and postoperative chemotherapy as well as a bilirubin level < 10 mg/dL are independent predictors of a significant increase in survival in patients with cholangiocarcinoma.
研究可能影响黎巴嫩胆管癌患者生存的因素。
对1990年至2005年间在美国贝鲁特大学诊断为胆管癌的55例患者的病历进行回顾性分析。进行单因素和多因素分析，以确定手术、化疗、体重指数、胆红素水平及其他因素对生存的影响。
所有患者的中位生存期为8.57个月（0.03 - 105.2个月）。单因素分析显示，低胆红素水平（<10mg/dL）、根治性手术及化疗与较好的生存显著相关（P分别为0.012、0.038和0.038）。在未接受手术的患者亚组分析中，化疗显著延长了中位生存期（17.0个月对3.5个月，P = 0.001）。多因素分析仅确定低胆红素水平<10mg/dL和化疗为与较好生存相关的独立预测因素（P < 0.05）。
我们的数据表明，姑息性化疗和术后化疗以及胆红素水平<10mg/dL是胆管癌患者生存显著增加 的独立预测因素。
