Bognar Gabor, Imdahl Andreas, Ledniczky György, Ondrejka Pal
2nd Department of Surgery, Semmelweis University Budapest, Budapest, Hungary.
Hepatogastroenterology. 2008 Jan-Feb;55(81):93-7.
BACKGROUND/AIMS: Human papilloma virus (HPV) infection in esophageal cancer cases has been found in 0-70%, depending on different methods and geographical variances. Complete pathological response has been found in 30% of cases after neoadjuvant chemo-radiation (CRX). The aim of this study was to discover a possible relation between HPV-infection and response.
DNA was obtained from 26 esophageal cancer patients undergoing CRX and surgery. Polymerase chain reaction (PCR) and Southern Blot hybridization was used to detect HPV-infection (HPV-16 and -18). Clinicopathological parameters, disease-free survival and overall survival were also analyzed.
Complete response (26.9%) and partial response (38.5%) after CRX was correlated significantly with better prognosis. Six patients had HPV-infection (3 from the CR- and 3 from PR-group).
There was correlation between HPV-infection and response, but further analyses are necessary. Both responder-groups had a significantly better prognosis than non-responders.
背景/目的：根据不同的检测方法和地域差异，食管癌患者中人乳头瘤病毒（HPV）感染率在0%至70%之间。新辅助放化疗（CRX）后，30%的病例出现了完全病理缓解。本研究的目的是探究HPV感染与治疗反应之间可能存在的关系。
从26例接受CRX及手术治疗的食管癌患者中获取DNA。采用聚合酶链反应（PCR）和Southern印迹杂交检测HPV感染（HPV - 16和 - 18）。同时分析临床病理参数、无病生存期和总生存期。
CRX后的完全缓解率（26.9%）和部分缓解率（38.5%）与较好的预后显著相关。6例患者存在HPV感染（完全缓解组3例，部分缓解组3例）。
HPV感染与治疗反应之间存在相关性，但仍需进一步分析。两个缓解组的预后均显著优于未缓解组。
