Department of Virology, School of Medicine, University of Crete, Heraklion, Greece.
Pathol Oncol Res. 2011 Mar;17(1):103-19. doi: 10.1007/s12253-010-9288-0. Epub 2010 Jul 18.
Recently, the vaccine against human papillomavirus (HPV) was introduced in the national vaccination programmes of several countries worldwide. The established association between HPV and the progression of cervical neoplasia provides evidence of the expected protection of the vaccine against cervical cancer. During the last two decades several studies have also examined the possible involvement of HPV in non-genital cancers and have proposed the presence of HPV in oesophageal, laryngeal, oropharyngeal, lung, urothelial, breast and colon cancers. The possible involvement of HPV in these types of cancer would necessitate the introduction of the vaccine in both boys and girls. However, the role of HPV in the pathogenesis of these types of cancer has yet to be proven. Moreover, the controversial evidence of the possible impact of the vaccination against HPV in the prevention of non-genital cancers needs to be further evaluated. In this review, we present an overview of the existing epidemiological evidence regarding the detection of HPV in non-genital cancers.
最近，人乳头瘤病毒（HPV）疫苗已在全球多个国家的国家免疫规划中推出。HPV 与宫颈癌进展之间的既定关联为疫苗预防宫颈癌提供了证据。在过去的二十年中，多项研究还研究了 HPV 可能在非生殖系统癌症中的作用，并提出 HPV 存在于食管、喉、口咽、肺、尿路上皮、乳腺和结肠癌症中。HPV 可能参与这些类型的癌症需要在男孩和女孩中引入疫苗。然而，HPV 在这些类型癌症发病机制中的作用尚未得到证实。此外，HPV 疫苗在预防非生殖系统癌症方面可能产生影响的有争议的证据需要进一步评估。在这篇综述中，我们介绍了关于非生殖系统癌症中 HPV 检测的现有流行病学证据概述。
