Charing Cross and Westminster Medical School (University of London) London UK.
Int J Cosmet Sci. 1997 Aug;19(4):167-72. doi: 10.1046/j.1467-2494.1997.171712.x.
Suspensions (20%) of microfine and ACS grade zinc oxide, or 20% titanium oxide in water, castor oil or polyethylene glycol were applied topically to rabbit skin over 4 h (1 day) or 2 h daily (3 days). Skin sites were analysed for metal uptake. Percutaneous absorption of the oxides was probably low, most remaining on the skin surface. Uptake patterns were influenced by the vehicles used. Appreciably more microfine zinc oxide was taken up by the skin in subacute studies. Local changes in trace metal concentration were construed as evidence of percutaneous absorption of zinc and titanium oxides. Further studies are indicated to validate the significance of these preliminary observations.
悬浮液（20%）的微粉和 ACS 级氧化锌，或 20%的二氧化钛在水中，蓖麻油或聚乙二醇被局部应用于兔子皮肤超过 4 小时（1 天）或每天 2 小时（3 天）。分析皮肤部位的金属吸收情况。氧化物的经皮吸收可能很低，大部分仍留在皮肤表面。吸收模式受所用载体的影响。在亚急性研究中，微粉氧化锌被皮肤吸收的量明显更多。痕量金属浓度的局部变化被认为是锌和钛氧化物经皮吸收的证据。需要进一步的研究来验证这些初步观察的意义。
