Wang Steven Q, Tooley Ian R
Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, NY 07920, USA.
Semin Cutan Med Surg. 2011 Dec;30(4):210-3. doi: 10.1016/j.sder.2011.07.006.
Commercial sunscreen based on nano-sized titanium dioxide (TiO(2)) and zinc oxide (ZnO) delivers superior UV protection and reduces whitening on skin compared to the older generations of inorganic sunscreens. This review discusses the historical use of nano-sized TiO(2) and ZnO in sunscreen and the relationship between UV attenuation and the primary particles, aggregates and agglomerates that make up these inorganic oxides. In addition we reviewed the recent safety concerns surrounding these materials, specifically, percutaneous penetration of TiO(2) and ZnO nanoparticles through human skin and their potential to cause phototoxicity.
与老一辈无机防晒霜相比，基于纳米二氧化钛（TiO₂）和氧化锌（ZnO）的商用防晒霜具有卓越的紫外线防护能力，且能减少皮肤泛白现象。本综述讨论了纳米TiO₂和ZnO在防晒霜中的历史应用，以及紫外线衰减与构成这些无机氧化物的初级颗粒、聚集体和团聚体之间的关系。此外，我们还综述了近期围绕这些材料的安全问题，特别是TiO₂和ZnO纳米颗粒经皮穿透人体皮肤及其引起光毒性的可能性。
