McCarthy Jason R, Weissleder Ralph
Center for Molecular Imaging Research, Harvard Medical School and Massachusetts General Hospital, 149 13th St., Rm 5406, Charlestown, MA 02129, USA.
Adv Drug Deliv Rev. 2008 Aug 17;60(11):1241-1251. doi: 10.1016/j.addr.2008.03.014. Epub 2008 Apr 10.
Magnetic nanoparticles have become important tools for the imaging of prevalent diseases, such as cancer, atherosclerosis, diabetes, and others. While first generation nanoparticles were fairly nonspecific, newer generations have been targeted to specific cell types and molecular targets via affinity ligands. Commonly, these ligands emerge from phage or small molecule screens, or are based on antibodies or aptamers. Secondary reporters and combined therapeutic molecules have further opened potential clinical applications of these materials. This review summarizes some of the recent biomedical applications of these newer magnetic nanomaterials.
磁性纳米颗粒已成为用于成像常见疾病（如癌症、动脉粥样硬化、糖尿病等）的重要工具。第一代纳米颗粒相当非特异性，而新一代则通过亲和配体靶向特定细胞类型和分子靶点。通常，这些配体来自噬菌体或小分子筛选，或基于抗体或适体。二级报告分子和联合治疗分子进一步开拓了这些材料的潜在临床应用。本综述总结了这些新型磁性纳米材料最近的一些生物医学应用。
