Martin Vera, Huber Martin, Rief Winfried, Exner Cornelia
Christoph-Dornier-Foundation for Clinical Psychology, Marburg, Universitätsstrasse 27, D-35037 Marburg, Germany.
Arch Clin Neuropsychol. 2008 Sep;23(5):487-500. doi: 10.1016/j.acn.2008.03.006. Epub 2008 Jun 3.
A body of neuropsychological research revealed cognitive impairments in patients suffering from obsessive-compulsive disorder (OCD). Only few investigations addressed the question of how specific these impairments are. The present study compared the performances of 19 subjects with OCD to 19 subjects with schizophrenia and 19 healthy controls on neuropsychological tasks across the main cognitive domains (memory, attention, visual spatial and executive functioning). For purposes of data-reduction, single test measures of the test battery applied were aggregated into eight cognitive domain scores. Contrary to our expectation we found comparable performance profiles of obsessive-compulsive (OC) and schizophrenia subjects across domains with impairments primarily affecting simple attentional skills and memory skills. However, deficits of subjects with schizophrenia were greater in magnitude than those of subjects with OCD on all domains assessed. Elevated depression scores exerted a relevant impact on performance deficits in the OC but not in the schizophrenia sample.
大量神经心理学研究表明，强迫症（OCD）患者存在认知障碍。只有少数研究探讨了这些障碍的具体程度。本研究将19名强迫症患者与19名精神分裂症患者以及19名健康对照者在主要认知领域（记忆、注意力、视觉空间和执行功能）的神经心理学任务表现进行了比较。为了进行数据简化，将所应用测试组合中的单项测试指标汇总为八个认知领域得分。与我们的预期相反，我们发现强迫症（OC）患者和精神分裂症患者在各领域的表现特征具有可比性，障碍主要影响简单注意力技能和记忆技能。然而，在所有评估领域，精神分裂症患者的缺陷程度均大于强迫症患者。抑郁得分升高对OC组的表现缺陷有显著影响，但对精神分裂症样本没有影响。
