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强迫症和精神分裂症中可分离的来源监测损伤。

Dissociable source-monitoring impairments in obsessive-compulsive disorder and schizophrenia.

机构信息

INSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, PSYR2 Team, LyonF-69000, France.

University Lyon 1, VilleurbanneF-69000, France.

出版信息

Eur Psychiatry. 2020 May 14;63(1):e54. doi: 10.1192/j.eurpsy.2020.48.

DOI:10.1192/j.eurpsy.2020.48
PMID:32406366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7355175/
Abstract

BACKGROUND

Based on the observed clinical overlap between obsessive-compulsive disorder (OCD) and schizophrenia (SCZ), both conditions may share, at least in part, common cognitive underpinnings. Among the cognitive deficits that could be involved, it has been hypothesized that patients share a failure in their abilities to monitor their own thoughts (source monitoring), leading to confusion between what they actually did or perceived and what they imagined. Although little is known regarding source-monitoring performances in patients with OCD, numerous studies in patients with SCZ have observed a relationship between delusions and/or hallucinations and deficits in both internal source- and reality-monitoring abilities.

METHODS

The present work compared source-monitoring performances (internal source and reality monitoring) between patients with OCD (n = 32), patients with SCZ (n = 38), and healthy controls (HC; n = 29).

RESULTS

We observed that patients with OCD and patients with SCZ displayed abnormal internal source-monitoring abilities compared to HC. Only patients with SCZ displayed abnormalities in reality monitoring compared to both patients with OCD and HC.

CONCLUSIONS

Internal source-monitoring deficits are shared by patients with OCD and SCZ and may contribute to the shared cognitive deficits that lead to obsessions and delusions. In contrast, reality-monitoring performance seems to differentiate patients with OCD from patients with SCZ.

摘要

背景

基于强迫症 (OCD) 和精神分裂症 (SCZ) 之间观察到的临床重叠，这两种病症可能至少部分地具有共同的认知基础。在可能涉及的认知缺陷中，有人假设患者在监测自己的思维的能力上存在缺陷（来源监测），导致他们实际做或感知到的和他们想象的之间混淆。尽管关于 OCD 患者的来源监测表现知之甚少，但许多 SCZ 患者的研究观察到妄想和/或幻觉与内部来源和现实监测能力缺陷之间存在关系。

方法

本研究比较了强迫症患者（n=32）、精神分裂症患者（n=38）和健康对照组（HC；n=29）的来源监测表现（内部来源和现实监测）。

结果

我们观察到，与 HC 相比，强迫症患者和精神分裂症患者的内部来源监测能力异常。只有精神分裂症患者的现实监测存在异常，与强迫症患者和 HC 相比。

结论

内部来源监测缺陷是 OCD 和 SCZ 患者共有的，可能导致强迫症和妄想的共同认知缺陷。相比之下，现实监测表现似乎可以区分强迫症患者和精神分裂症患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df9/7355175/6b6e0f4b9025/S0924933820000486_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df9/7355175/3e07e0f39ba6/S0924933820000486_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df9/7355175/05198160e3c1/S0924933820000486_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df9/7355175/6b6e0f4b9025/S0924933820000486_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df9/7355175/3e07e0f39ba6/S0924933820000486_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df9/7355175/05198160e3c1/S0924933820000486_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df9/7355175/6b6e0f4b9025/S0924933820000486_fig3.jpg

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