牙龈蛋白酶依赖性与宿主的相互作用对牙龈卟啉单胞菌的生存至关重要。
Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis.
作者信息
Sheets Shaun M, Robles-Price Antonette G, McKenzie Rachelle M E, Casiano Carlos A, Fletcher Hansel M
机构信息
Department of Biochemistry and Microbiology, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA.
出版信息
Front Biosci. 2008 May 1;13:3215-38. doi: 10.2741/2922.
Abstract
Porphyromonas gingivalis, a major periodontal pathogen, must acquire nutrients from host derived substrates, overcome oxidative stress and subvert the immune system. These activities can be coordinated via the gingipains which represent the most significant virulence factor produced by this organism. In the context of our contribution to this field, we will review the current understanding of gingipain biogenesis, glycosylation, and regulation, as well as discuss their role in oxidative stress resistance and apoptosis. We can postulate a model, in which gingipains may be part of the mechanism for P. gingivalis virulence.
摘要
牙龈卟啉单胞菌是一种主要的牙周病原体，必须从宿主衍生的底物中获取营养，克服氧化应激并颠覆免疫系统。这些活动可以通过牙龈蛋白酶来协调，牙龈蛋白酶是该生物体产生的最重要的毒力因子。在我们对该领域贡献的背景下，我们将回顾目前对牙龈蛋白酶生物合成、糖基化和调节的理解，并讨论它们在抗氧化应激和细胞凋亡中的作用。我们可以假定一个模型，其中牙龈蛋白酶可能是牙龈卟啉单胞菌毒力机制的一部分。
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