Ashman Robert B
School of Dentistry, University of Queensland, Brisbane, Queensland 4072, Australia.
Front Biosci. 2008 May 1;13:3334-51. doi: 10.2741/2929.
Candida albicans is an important opportunistic fungal pathogen. Clinical observations have indicated that both innate and adaptive immune responses are involved in recovery from initial infection, but analysis in murine models has shown that the contribution of the two arms of the cellular immune response differ in oral, vaginal, and systemic infections. The relative contributions of T cells and phagocytic cells, and the cytokines that mediate their interactions are discussed for each of the different manifestations of the disease, and the consequences of infection, in terms of protection and pathology, are evaluated.
白色念珠菌是一种重要的机会性真菌病原体。临床观察表明，先天免疫反应和适应性免疫反应均参与了初始感染后的恢复过程，但对小鼠模型的分析表明，细胞免疫反应的两个分支在口腔、阴道和全身感染中的作用有所不同。针对该疾病的每种不同表现形式，讨论了T细胞和吞噬细胞的相对作用以及介导它们相互作用的细胞因子，并从保护和病理学角度评估了感染的后果。
