Kashem Sakeen W, Kaplan Daniel H
Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Departments of Dermatology and Immunology, University of Pittsburgh, Pittsburgh, PA 15216, USA.
Trends Immunol. 2016 Jul;37(7):440-450. doi: 10.1016/j.it.2016.04.007. Epub 2016 May 10.
Candida albicans is a dimorphic commensal fungus that colonizes healthy human skin, mucosa, and the reproductive tract. C. albicans is also a predominantly opportunistic fungal pathogen, leading to disease manifestations such as disseminated candidiasis and chronic mucocutaneous candidiasis (CMC). The differing host susceptibilities for the sites of C. albicans infection have revealed tissue compartmentalization with tailoring of immune responses based on the site of infection. Furthermore, extensive studies of host genetics in rare cases of CMC have identified conserved genetic pathways involved in immune recognition and the response to the extracellular pathogen. We focus here on human and mouse skin as a site of C. albicans infection, and we review established and newly discovered insights into the cellular pathways that promote cutaneous antifungal immunity.
白色念珠菌是一种双态共生真菌，可定植于健康人体的皮肤、黏膜和生殖道。白色念珠菌也是一种主要的机会性真菌病原体，可导致播散性念珠菌病和慢性黏膜皮肤念珠菌病（CMC）等疾病表现。白色念珠菌感染部位不同的宿主易感性揭示了组织分区化，即基于感染部位定制免疫反应。此外，对罕见CMC病例中宿主遗传学的广泛研究已经确定了参与免疫识别和对细胞外病原体反应的保守遗传途径。我们在此重点关注白色念珠菌感染部位之一的人类和小鼠皮肤，并综述关于促进皮肤抗真菌免疫的细胞途径的已确立和新发现的见解。
