Traidl-Hoffmann C, Eyerich K, Maier E, Behrendt H, Ring J, Hofmann H
Klinik und Poliklinik für Dermatologie und Allergologie, Technische Universität München.
Dtsch Med Wochenschr. 2010 Jul;135(27):1379-88; quiz 1389-92. doi: 10.1055/s-0030-1262423. Epub 2010 Jun 29.
Infection with the yeast candida is a quite common disease. Its occurrence might be harmless, however, Candida infections often present with an underlying systemic disease. Thus, candidiasis in some cases can be considered as an indicator for e.g. diabetes mellitus or immune deficiency (i.e. HIV or leukaemia). Of note, we have to distinguish the colonisation and the infection with Candida because only the presence of the yeast together with clinical symptoms is an indication for treatment. The latter has to be adapted according to age, localisation and potentially underlying systemic disease. A special form of Candidiasis constitutes the chronic mucocutaneous candidiasis which can occur in line with hereditary immune deficiencies or also isolated. In the present review we discuss the current status of diagnostic and therapy of mucocutaneous candidiasis as well as the (patho-) immunologic background of yeast infections using the example of a special case of chronic mucocutaneous candidiasis.
酵母菌念珠菌感染是一种相当常见的疾病。其发生可能无害，然而，念珠菌感染往往伴有潜在的全身性疾病。因此，在某些情况下，念珠菌病可被视为例如糖尿病或免疫缺陷（即艾滋病毒或白血病）的一个指标。值得注意的是，我们必须区分念珠菌的定植和感染，因为只有酵母菌的存在以及临床症状才是治疗的指征。后者必须根据年龄、感染部位以及潜在的全身性疾病进行调整。念珠菌病的一种特殊形式是慢性黏膜皮肤念珠菌病，它可能与遗传性免疫缺陷同时发生，也可能单独出现。在本综述中，我们以慢性黏膜皮肤念珠菌病的一个特殊病例为例，讨论黏膜皮肤念珠菌病的诊断和治疗现状以及酵母菌感染的（病理）免疫背景。
